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typhoid Vi polysaccharide vaccine
- Development stage
- Unknown
- Lead developer
- Finlay Vaccine Institute
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular, Subcutaneous
01
Overview
vax-TyVi is a Vi polysaccharide vaccine developed by the Finlay Vaccine Institute for the prevention of typhoid fever. The vaccine is composed of the purified Vi capsular polysaccharide antigen extracted from *Salmonella enterica* serovar Typhi. Upon administration, it induces a T-cell independent immune response, stimulating the production of specific IgG antibodies against the Vi antigen, which provides protective immunity against infection. vax-TyVi is approved for use in adults and children (typically over two years of age) who are at risk of typhoid fever, particularly in endemic regions or for travelers.
- Brand names
- vax-TyVi
- Other names
- vax-TyVi vaccineFinlay typhoid vaccineTyphoid Vi polysaccharide vaccine
02
Targets
Vi polysaccharide-specific B-cell receptor
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