tyramine

Tyramine is an endogenous trace amine and orally bioactive small molecule monoamine that has been used mainly as a pharmacologic probe and challenge agent rather than as an approved therapeutic drug. It acts primarily as an indirect sympathomimetic: it is taken up into adrenergic nerve terminals and promotes displacement and release of stored norepinephrine, producing vasoconstrictor and pressor effects and other sympathetic responses. In the provided literature, tyramine was administered intra-arterially, intravenously, orally, and ophthalmically to study sympathetic neurotransmission, vascular responses, migraine biology, depressive illness, Parkinson disease, multiple system atrophy, autonomic failure, and metabolic responses in diabetes. Although tyramine is a real and publicly documented drug substance, it does not appear from the provided context to be an actively developed sponsor-owned therapeutic asset for a modern indication; its use in these sources is predominantly experimental, diagnostic-physiologic, or challenge-test based.

Other names

4-hydroxyphenethylaminep-tyraminetyramine hydrochloridetyramine sulfate