Drug intelligence / Profile preview

tyrosinase + MAGE-3 + GnTV

Development stage
Phase 2
Modality
Peptides, Vaccines & Immunotherapeutics
Administration
Subcutaneous
01

Overview

This is a **synthetic multiepitope peptide vaccine** formulation composed of peptides derived from **tyrosinase**, **MAGE-3** (Melanoma Antigen Gene A3), and **GnTV** (N-acetylglucosaminyltransferase V, also referred to as GnT-V). The vaccine is designed to induce **cellular immune responses**, especially cytotoxic T lymphocyte (CTL) activity, against tumors expressing these antigens, primarily **melanoma**. Administration is typically combined with immune adjuvants such as **KLH (keyhole limpet hemocyanin)** and **GM-CSF (granulocyte-macrophage colony-stimulating factor)** to enhance immunogenicity. The approach aims to stimulate T-cell responses recognizing tumor-associated antigens, promoting anti-tumor immunity in cancer patients, especially those with advanced melanoma[3][5][8]. The vaccine does not have a unique commercial or code name, and it is used primarily in investigational settings.

02

Targets

MHC class I/II molecules presenting MAGE-A3-derived peptidespMHC-tyrosinase (MHC class I/II molecules presenting tyrosinase-derived peptides)MHC-I/GnTV (Major histocompatibility complex class I molecules presenting N-acetylglucosaminyltransferase V-derived peptides)

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