Drug intelligence / Profile preview

tyrosine

Development stage
Phase 2
Modality
Small Molecules
Administration
Oral
01

Overview

Tyrosine is a non-essential aromatic amino acid with the chemical formula C9H11NO3. It is synthesized in animals from phenylalanine and serves as a precursor for several important biomolecules including catecholamine neurotransmitters such as dopamine, norepinephrine, and epinephrine; thyroid hormones; and melanin pigment[1][8]. Tyrosine plays a critical role in protein synthesis and cellular signaling due to its phenolic side chain, which can be phosphorylated by protein kinases—a key step in many signal transduction pathways[2][5]. In clinical settings, tyrosine is used as a component of parenteral nutrition solutions to support protein synthesis in patients unable to eat normally[8]. It also has roles in photosynthesis and other metabolic processes.

Brand names
Aminosyn-PF 7%Clinimix 2.75/5Clinimix E 2.75/5Clinisol 15Clinisol15Clinisol-15OlimelPeriolimelPlenaminePremasolPrimeneProsolTravasol 10Travasol10Travasol-10Trophamine 10 %
Other names
(−)-α-amino-p-hydroxyhydrocinnamic acid(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid(S)-(-)-Tyrosine(S)-2-Amino–3-(p-hydroxyphenyl)propionic acid(S)-3-(p-Hydroxyphenyl)alanine(S)-alpha-amino–4-Hydroxybenzenepropanoic acidL-TyrosinTirosinaα-Amino–β-(4-hydroxyphenyl)propionic acidBenzenepropanoic acid, α-amino–4-hydroxy-, (S)-L-p-TyrosineL‑Phenylalanine, 4‑hydroxy-Propanoic acid, 2‑amino‑3‑(4‑hydroxyphenyl)-NSC 82624NSC82624NSC-82624
02

Targets

TH (Tyrosine hydroxylase)aaRS (Aminoacyl-tRNA synthetase family)

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