tyrphostin ag 835

Tyrphostin AG 835 is a synthetic small molecule belonging to the tyrphostin family of protein tyrosine kinase inhibitors. It is best known as a selective inhibitor of receptor tyrosine kinases, particularly the epidermal growth factor receptor (EGFR), with reported inhibitory activity in the low micromolar range. Tyrphostin AG 835 has been widely used in cancer research to study tumor cell proliferation and survival by blocking EGFR-mediated signaling pathways. Additionally, it serves as a tool compound for dissecting growth factor signaling in neuroscience and cell biology research. Its mechanism involves competitive inhibition at the ATP-binding site of EGFR and potentially other related kinases[1][5][7].

Other names

AG 835AG835AG-835TYRPHOSTIN B50(+)-EnantiomerTYRPHOSTIN B44, (+) ENANTIOMERTyrphostin B44, (+) enantiomer AG835(S)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(1-phenylethyl)acrylamidealpha-cyano-(+)-(S)-N-(alpha-PHENETHYL)-(3,4-DIHYDROXY)cinnamide