tyrphostin AG1478

Tyrphostin AG1478 (also known as AG1478) is a potent, selective, and reversible small-molecule inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 3 nM. Developed as part of the tyrphostin class of tyrosine kinase inhibitors, it competitively binds to the ATP-binding site of the EGFR kinase domain. Beyond its primary target, AG1478 has been shown to inhibit phosphatidylinositol 4-kinase alpha (PI4KA) and the Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (GBF1), which contributes to its broad-spectrum antiviral activity against viruses such as encephalomyocarditis virus (EMCV), hepatitis C virus (HCV), and influenza A. It is widely utilized as a research reagent to study EGFR-mediated signaling pathways, cell proliferation, migration, and tissue remodeling in various preclinical models of cancer, asthma, and polycystic kidney disease.

Other names

4-(3-chloroanilino)-6,7-dimethoxyquinazolineN-(3-chlorophenyl)-6,7-dimethoxy-4-quinazolinamineN-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine