tyrphostin b44

Tyrphostin B44 is a synthetic small molecule inhibitor of protein tyrosine kinases, specifically targeting the epidermal growth factor receptor (EGFR) kinase. It acts by competitively inhibiting the ATP-binding site of EGFR, thereby blocking downstream signaling pathways involved in cell proliferation and survival. The compound has demonstrated antitumor activity in vitro with an IC50 of approximately 0.86 µM for EGFR kinase and exhibits cytotoxic effects against various cancer cell lines[3][4][7]. It is primarily used as a research tool to study signal transduction pathways mediated by receptor tyrosine kinases such as EGFR[1][2]. There are two enantiomers; the (-) enantiomer (tyrphostin B44) is more active than the (+) form.

Other names

tyrphostin b44tyrphostin b44, (-) enantiomer