tyrphostin b48

Tyrphostin B48 is a synthetic small molecule that functions as a potent and selective inhibitor of protein tyrosine kinases, particularly the epidermal growth factor receptor (EGFR) kinase. It belongs to the tyrphostin family of compounds characterized by their hydroxy-benzylidenemalononitrile pharmacophore. Tyrphostin B48 inhibits EGFR kinase activity and has been used experimentally to study signal transduction pathways involving EGFR and related kinases. It also inhibits nuclear localization of the aryl hydrocarbon receptor (AhR) induced by dioxins in cell models. The compound is primarily used as a research tool in cancer biology and signal transduction studies[1][2][5][10].

Other names

alpha-cyano-(3,4-dihydroxy)-N-phenylcinnamide(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-phenylprop-2-enamideN-phenyI 3,4-dihydroxybenzylidenecyanoacetamide