Drug intelligence / Profile preview

Tyvaso DPI

Development stage
Approved
Lead developer
United Therapeutics
Modality
Small Molecules
Administration
Inhalation
01

Overview

Tyvaso DPI is an inhaled dry powder formulation of treprostinil, a prostacyclin mimetic. It is indicated for the treatment of pulmonary arterial hypertension (PAH; WHO Group 1) and pulmonary hypertension associated with interstitial lung disease (PH-ILD; WHO Group 3), both to improve exercise ability. Treprostinil acts as a prostacyclin analogue, exerting its effects primarily through direct vasodilation of pulmonary and systemic arterial vascular beds and inhibition of platelet aggregation. The drug is administered via a handheld dry powder inhaler device, typically four times daily in single-breath doses per cartridge[2][5][7][9]. Tyvaso DPI was approved by the FDA in 2022 for these indications[7].

Brand names
Tyvaso DPI
Other names
treprostinil inhalation powder
02

Targets

PTGIR (Prostanoid IP Receptor)PTGER2 (Prostaglandin E2 receptor EP2)PTGDR (Prostanoid DP1 receptor)

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