Drug intelligence / Profile preview

U-47700

Development stage
Unknown
Lead developer
Pfizer
Modality
Small Molecules
Administration
Oral, Intranasal, Intravenous, Inhalation
01

Overview

U-47700 is a potent synthetic opioid analgesic originally developed by The Upjohn Company in the 1970s. It acts as a selective agonist for the mu-opioid receptor, with a potency estimated to be approximately 7.5 times that of morphine in animal models. Although intended for the treatment of severe pain, the compound never underwent clinical trials in humans and was never approved for medical use. In the mid-2010s, it surfaced on the illicit drug market as a novel psychoactive substance (NPS), often referred to by street names such as 'pink' or 'U4.' Due to its high potential for abuse and association with numerous fatal overdoses, it has been classified as a Schedule I controlled substance in the United States.

Other names
pinkpinkypink heroinU4U-4U 4trans-3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide
02

Targets

KOR (Kappa opioid receptor)DOR (Opioid Receptor Delta 1)MOR (Mu opioid receptor)

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