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Drug intelligence / Profile preview
U-Signal
- Development stage
- Preclinical
- Lead developer
- U-factor
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intramuscular, Intranasal, Intravenous
01
Overview
U-Signal is a cell-free regenerative medicine product consisting of a highly purified culture supernatant derived from human exfoliated deciduous-tooth dental pulp stem cells (SHED-CM). Developed by U-Factor and clinically utilized by Hitonowa Medical, U-Signal contains over 2,500 proteins, cytokines, and growth factors (including VEGF, HGF, and MCP-1), as well as exosomes. It is designed to modulate neural and surrounding cellular environments, promoting neuroprotection, nerve regeneration, and tissue repair. U-Signal is administered via intravenous drip, intranasal spray, or intramuscular injection, and is being investigated and clinically applied for various neurodegenerative and inflammatory conditions, including amyotrophic lateral sclerosis (ALS), post-stroke sequelae, dementia, Parkinson's disease, and rheumatoid arthritis.
- Brand names
- U-Signal
- Other names
- SHED-CMU-Factor solutionU-Factor液deciduous-tooth pulp stem cell culture supernatantdental pulp stem cell culture supernatant歯髄幹細胞培養上清液
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