U73872

U73872 is a pharmacological inhibitor of phospholipase C (PLC) that has been utilized in preclinical research to investigate the signaling pathways driving glioblastoma multiforme (GBM) progression. Specifically, it is used to study the role of the PLCγ1 and Pyk2 signaling cascade in mediating glioma cell migration and dispersal in response to microglial activation. In experimental models involving various rodent and human glioma cell lines (such as U-87MG and A172), U73872 has been shown to block the stimulatory effects of microglia on tumor cell invasion. It is important to note that the name 'U73872' is widely recognized as a typographical error in the source literature for the well-established PLC inhibitor **U-73122**.