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UAMC-00150
- Development stage
- Preclinical
- Lead developer
- University of Antwerp
- Modality
- Small Molecules
- Administration
- Intraperitoneal, Intravenous
01
Overview
UAMC-00150 is a small molecule, nonpeptidic, irreversible diaryl phosphonate inhibitor of trypsin-like serine proteases, specifically targeting urokinase-type plasminogen activator (uPA) and neuropsin (kallikrein-related peptidase 8, KLK8). Developed by the University of Antwerp, the compound features a diphenyl phosphonate group that covalently binds to the active-site serine residue of target proteases, and a benzylguanidine group that enhances potency and selectivity. UAMC-00150 has been investigated for its potential to inhibit cancer invasion and metastasis by blocking uPA-mediated extracellular matrix (ECM) degradation. Additionally, its hydrochloride salt form, UAMC-01162, has been studied in neurobiology for its effects on synaptic plasticity, network synchronization, and epilepsy, as well as in other serine protease-mediated conditions.
- Other names
- compound 6ccompound6ccompound-6c
02
Targets
PLAU (uPA)KLK (Tissue kallikrein family)
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