UAMC3203

UAMC3203 is a potent, second-generation small molecule inhibitor of ferroptosis, an iron-dependent form of regulated cell death characterized by the accumulation of lipid peroxides. Developed by the University of Antwerp as a more metabolically stable and potent analog of Ferrostatin-1, UAMC3203 functions as a radical-trapping antioxidant (RTA). It effectively scavenges lipid peroxyl radicals, thereby halting the chain reaction of lipid peroxidation that leads to membrane rupture and cell death. Preclinical research, including studies presented at AACR 2024, highlights its potential therapeutic application in treating nonalcoholic steatohepatitis (NASH), hepatic steatosis, and preventing the progression to hepatocellular carcinoma (HCC) by mitigating oxidative stress-induced liver damage.