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UB-923

Development stage: Preclinical
Lead developer: United BioPharma
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intravenous

Overview

UB-923 is a preclinical-stage afucosylated monoclonal antibody developed by United BioPharma (UBP) that targets the CD20 antigen. CD20 is a protein expressed on the surface of B cells and is a well-validated target for the treatment of B-cell malignancies. By utilizing afucosylation technology, UB-923 is engineered to have a higher affinity for the FcγRIIIa receptor on effector cells, such as natural killer (NK) cells, thereby significantly enhancing antibody-dependent cellular cytotoxicity (ADCC) compared to non-modified anti-CD20 antibodies. The drug is being developed for the treatment of various B-cell lymphoproliferative disorders, including non-Hodgkin lymphoma, chronic lymphocytic leukemia, and follicular lymphoma.

Other names: afucosylated anti-CD20 monoclonal antibody

Targets

CD20 (B-lymphocyte antigen CD20)

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