ubenimex

Ubenimex is a small molecule competitive and reversible protease inhibitor derived from Streptomyces olivoreticuli. It inhibits several aminopeptidases, including aminopeptidase B (arginyl aminopeptidase), leukotriene A4 hydrolase (a zinc metalloprotease with both epoxide hydrolase and aminopeptidase activities), alanyl aminopeptidase (aminopeptidase N/M), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), and membrane dipeptidases. Ubenimex has been used as an adjunct to chemotherapy for acute non-lymphocytic leukemia in adults under the brand name Bestatin. It is also being investigated for other indications such as pulmonary arterial hypertension, lymphedema, lung cancer, nasopharyngeal cancer, hypercholesterolemia, and melanoma. Its mechanism of action involves inhibition of peptide-degrading enzymes that regulate bioactive peptides involved in tumor growth and immune response[1][2][4][5].

Brand names

Bestatin

Other names

ubenimex hydrochlorideubenimex HCl