Drug intelligence / Profile preview

ubidecarenone nanodispersion

Development stage
Phase 2
Lead developer
BPGBio
Modality
Small Molecules, Nanoparticles → Drug Delivery Systems
Administration
Intravenous
01

Overview

BPM31510-IV is an Ubidecarenone (CoQ10) drug-lipid conjugate nanodispersion that targets the metabolic machinery in cancer cells. It works by shifting bioenergetics from lactate dependency towards mitochondrial oxidative phosphorylation (OxPhos), which generates reactive oxygen species (ROS) and activates apoptosis. The drug modulates mitochondrial function in aggressive tumors, inducing a hallmark shift in the tumor microenvironment (TME) that leads to cancer cell death. In mitochondrial diseases, BPM31510-IV helps restore CoQ10 levels to overcome the effects of mutations that cause mitochondrial dysfunction.

Other names
Coenzyme Q10 injectable nanosuspensionCoQ10 injectable nanosuspensionCoQ-10 injectable nanosuspensionCoQ 10 injectable nanosuspensionUbiquinone injectable nanosuspension
02

Targets

OXPHOS (Mitochondrial OXPHOS complexes)BCL-2 (BCL-2 family)

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