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UBP-alloNK-Her2
- Development stage
- Preclinical
- Lead developer
- UWELL Biopharma
- Modality
- CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
UBP-alloNK-Her2 is an allogeneic chimeric antigen receptor natural killer (CAR-NK) cell therapy being developed by UWELL Biopharma for the treatment of HER2-expressing solid tumors. The therapy involves engineering natural killer cells from a healthy donor (allogeneic) to express a chimeric antigen receptor (CAR) specific for the Human Epidermal Growth Factor Receptor 2 (HER2). This modification enables the NK cells to selectively recognize and eliminate tumor cells that overexpress HER2. Currently in the preclinical stage (CAR engineering), UBP-alloNK-Her2 aims to provide an off-the-shelf cellular immunotherapy option, potentially overcoming the limitations of autologous CAR-T therapies such as manufacturing time and cost.
02
Targets
ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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