UBS109

**UBS109** is a synthetic small molecule belonging to the class of monocarbonyl analogs of curcumin. It is designed to overcome the limitations of natural curcumin, notably improving solubility and metabolic stability. UBS109 exerts its effects primarily as a potent inhibitor of the NF-kappaB pathway, contributing to strong anticancer activity including cytotoxicity against several cancer cell lines (such as MDA-MB-231 breast cancer and Tu212 head and neck carcinoma)[1][3][4][5][7]. The compound acts by interfering with cellular signaling involved in inflammation and cancer proliferation and has been shown to inhibit osteoclastogenesis, stimulate osteoblastogenesis and mineralization, and suppress cancer cell growth and metastasis in preclinical models[3][7].

Other names

(3E,5E)-1-Methyl-3,5-bis(2-pyridinylmethylene)-4-piperidinoneMonocarbonyl Analog of Curcumin