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UBX-303061

Development stage: Phase 1
Lead developer: Ubix Therapeutics
Modality: PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
Administration: Oral

Overview

UBX-303061 is an investigational small molecule drug developed by Ubix Therapeutics for the treatment of B-cell malignancies, specifically relapsed or refractory B-cell lymphoma. It functions as a proteolysis-targeting chimera (PROTAC) designed to degrade Bruton’s tyrosine kinase (BTK), a key enzyme involved in B-cell receptor signaling and survival. By promoting targeted degradation of BTK, UBX-303061 aims to disrupt malignant B-cell growth and survival pathways. The drug is currently being evaluated in first-in-human Phase 1 clinical trials for patients who have failed at least two prior therapies[1][4][9].

Targets

CRL4-CRBN (Cereblon-based E3 ubiquitin ligase complex)BTK (Bruton tyrosine kinase)

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