UCB-Exos

UCB-Exos are exosomes derived from human umbilical cord blood (UCB) plasma, currently under investigation for their neuroprotective potential in neurodegenerative disorders, particularly Parkinson's disease. These extracellular vesicles, ranging from 30 to 200 nm in diameter, carry a cargo of proteins, RNA, and DNA that can cross the blood-brain barrier to modulate neuronal function. In preclinical models of Parkinson's disease, UCB-Exos have demonstrated the ability to attenuate dopaminergic neuron loss, reduce neuroinflammation by inhibiting microglial activation, and promote neuronal regeneration. The therapeutic mechanism is primarily driven by the inhibition of hyperphosphorylation in the MAPK p38 and ERK 1/2 signaling pathways, which is achieved through the transcriptional regulation of HspB1 and Ppef2. UCB-Exos are considered a promising cell-free alternative to stem cell therapy due to their stability, low immunogenicity, and ease of access from young donor tissue.

Other names

umbilical cord blood-derived exosomeshuman umbilical cord blood-derived exosomesUCB plasma-derived exosomes