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ucb mononuclear cells + uc-msc exosomes

Development stage: Unknown
Lead developer: Anhui Provincial Tumor Hospital
Modality: Cell Therapies, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration: Intravenous

Overview

UCB mononuclear cells + UC-MSC exosomes is a combination biologic therapy being investigated for the treatment of radiation pneumonitis. The therapy consists of mononuclear cells derived from umbilical cord blood (UCB-MNCs) and exosomes harvested from umbilical cord-derived mesenchymal stem cells (UC-MSC-Exos). UCB-MNCs provide a diverse population of progenitor and immune cells that may contribute to tissue repair, while UC-MSC exosomes act as paracrine mediators, delivering a cargo of anti-inflammatory proteins and microRNAs to the site of injury. This dual approach aims to mitigate the inflammatory cascade and fibrotic changes associated with radiation-induced lung damage, potentially improving clinical outcomes for cancer patients undergoing thoracic radiotherapy.

Other names: UCB mononuclear cells + UC-MSC exosomesumbilical cord blood mononuclear cells combined with umbilical cord mesenchymal stem cell-derived exosomes

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