UCD74A

UCD74A (5-glycinyl amiloride) is a cell-impermeant, 5-substituted amiloride derivative developed by researchers at the University of California, Davis. It functions as a competitive inhibitor of the urokinase-type plasminogen activator (uPA) and also inhibits the sodium-hydrogen exchanger 1 (NHE1). Unlike its cell-permeant congener UCD38B, UCD74A exhibits poor cell permeability and is cytostatic rather than cytotoxic. It is primarily utilized as a research tool to investigate the roles of extracellular versus intracellular uPA and NHE1 signaling in cancer cell migration, invasion, and programmed necrotic cell death.

Other names

5-glycinyl amiloride5-glycinyl-amilorideglycinyl-amilorideUCD74A HClUCD-74A HClUCD 74A HClUCD74A hydrochlorideUCD-74A hydrochlorideUCD 74A hydrochloride