UCP1 activating compound

UCP1 activating compound (chemically known as ethyl 5-amino-4-[(2-methoxyphenyl)carbamoyl]-3-methylthiophene-2-carboxylate) is a small molecule uncoupling protein 1 (UCP1) activator. Identified through high-throughput screening of a structurally diverse compound library, it directly promotes thermogenesis in adipocytes with negligible cytotoxicity. In preclinical diet-induced obesity models, treatment with this compound slows weight gain, improves insulin sensitivity, and increases energy expenditure. Mechanistically, it enhances mitochondrial biogenesis by elevating maximal respiration, an effect partially mediated by the protein kinase A (PKA)-p38 mitogen-activated protein kinase (MAPK) signaling pathway.

Other names

2-amino-5-(2-methoxy-phenylcarbamoyl)-4-methyl-thiophene-3-carboxylic acid ethyl esterethyl 2-amino-5-(2-methoxyphenylcarbamoyl)-4-methylthiophene-3-carboxylateethyl 2-amino-5-[(2-methoxyphenyl)carbamoyl]-4-methylthiophene-3-carboxylateethyl 5-amino-4-([2-methoxyphenyl]carbamoyl)-3-methylthiophene-2-carboxylateethyl 5-amino-4-[(2-methoxyphenyl)carbamoyl]-3-methylthiophene-2-carboxylateUCP1 activatorUCP-1 activatorUCP 1 activatorUCP1-activating compoundUCP-1-activating compoundUCP 1-activating compound