Udenafil + donepezil

Udenafil + donepezil is a combination of two small molecule drugs. Udenafil is a phosphodiesterase type 5 (PDE5) inhibitor primarily developed for the treatment of erectile dysfunction. Donepezil is an acetylcholinesterase inhibitor used to treat cognitive symptoms associated with Alzheimer's disease and other dementias. The combination has been investigated in clinical trials for potential benefits in cognitive function in Alzheimer's disease patients[4]. Udenafil works by inhibiting PDE5 to increase cyclic GMP levels and promote vasodilation. Donepezil increases acetylcholine concentrations at cholinergic synapses by reversibly inhibiting acetylcholinesterase, thereby improving memory and cognition[1][2][3][5][6].