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uFab-800F
- Development stage
- Preclinical
- Lead developer
- Monopar Therapeutics
- Modality
- Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
uFab-800F is a fluorescently labeled antibody fragment designed for fluorescence-guided surgery (FGS) of solid tumors. It is derived from MNPR-101, a humanized monoclonal antibody that targets the urokinase plasminogen activator receptor (uPAR), a protein frequently overexpressed in various aggressive cancers. The compound consists of a Fab fragment (uFab) of MNPR-101 conjugated to the near-infrared fluorescent dye IRDye 800CW. By binding to uPAR with nanomolar affinity, uFab-800F allows for the real-time visualization of tumor margins and micrometastases during surgical procedures, potentially improving resection accuracy. It has demonstrated high tumor-to-background ratios in preclinical subcutaneous tumor models.
- Other names
- MNPR-101-Fab-800CWMNPR101-Fab-800CWMNPR 101-Fab-800CWuFab-IRDye 800CWuFab-IRDye800CWuFab-IRDye-800CW
02
Targets
PLAUR (Urokinase plasminogen activator receptor)
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