Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
ugonin J
- Development stage
- Preclinical
- Lead developer
- Arjil Biotech
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Ugonin J is a bioactive prenylated flavonoid (specifically a cyclohexylmethyl flavonoid) isolated from the roots of the medicinal fern *Helminthostachys zeylanica*. It exhibits a wide range of pharmacological activities, including antioxidant, anti-inflammatory, anti-diabetic, anti-cancer, and antiviral properties. In preclinical studies, Ugonin J has been shown to suppress hepatocyte inflammation by enhancing glutathione peroxidase 2 (GPX2)-mediated redox regulation and reducing reactive oxygen species (ROS) levels. It also acts as an inhibitor of the SARS-CoV-2 3C-like protease (3CLpro), downregulates NANOG to suppress breast cancer stem cells, and inhibits prostate cancer progression by targeting the PI3K/Akt/NF-κB pathway and reducing ADAM9 expression. Additionally, it has demonstrated potential in ameliorating non-alcoholic fatty liver disease (NAFLD) and metabolic disorders via AMPK/Akt pathway regulation.
- Other names
- UJUgonin J
02
Targets
Sucrase-IsomaltaseMpro (3C-like proteinase of SARS-CoV-2)PTPN1 (Protein tyrosine phosphatase 1B)
Beyond the preview
Go deeper on ugonin J.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on ugonin J.