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UIO-S26 is a preclinical RNA therapy candidate being developed by TransCode Therapeutics for the treatment of colorectal liver metastasis. The drug candidate was part of the portfolio associated with Polynoma LLC, which was acquired by TransCode Therapeutics. UIO-S26 is part of a broader series of RNA-based therapeutics (including UIO-S24 and UIO-S25) resulting from collaborations, such as those with the University of Oslo. While the specific molecular target and mechanism of action for UIO-S26 have not been publicly disclosed in company pipeline documentation, it is designed to address metastatic disease in the liver originating from colorectal cancer.
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