UK-369,003 + sildenafil

**UK-369,003 + sildenafil** is an investigational combination of two **phosphodiesterase type 5 (PDE5) inhibitors**. UK-369,003 is a selective and potent PDE5 inhibitor developed for oral bioavailability, dose-proportional pharmacokinetics, and efficacy in lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Sildenafil, best known under the brand names Viagra and Revatio, is an established PDE5 inhibitor used for erectile dysfunction and pulmonary arterial hypertension. Both drugs act by inhibiting the PDE5 enzyme, leading to increased levels of cyclic GMP, promoting smooth muscle relaxation and increased blood flow in target tissues. The combination is being studied for additive or synergistic effects, particularly in patients with LUTS and erectile dysfunction.

Brand names

ViagraRevatio

Other names

UK-369003UK369003UK 369003sildenafil citrate