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ULREA-PVS-NP

Development stage: Phase 1
Lead developer: Kyushu University
Modality: Nanoparticles → Drug Delivery Systems, Small Molecules
Administration: Intravenous

Overview

ULREA-PVS-NP is an intravenous nanoparticle formulation of pitavastatin encapsulated in poly(lactic-co-glycolic acid) (PLGA), developed by researchers at Kyushu University. This therapeutic candidate is designed to treat retinitis pigmentosa (RP), a rare inherited retinal degenerative disease characterized by progressive visual field loss. The formulation utilizes PLGA nanoparticles to deliver pitavastatin, an HMG-CoA reductase inhibitor, to target and suppress the activity of inflammatory monocytes and macrophages in the retina. By modulating these inflammatory pathways, ULREA-PVS-NP aims to prevent photoreceptor degeneration and slow the progression of vision loss. It is currently undergoing Phase 1 clinical evaluation to assess its safety, tolerability, and pharmacokinetics in patients with RP.

Other names: pitavastatin PLGA nanoparticlespitavastatin PLGA nano-particle

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)

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