Drug intelligence / Profile preview

Ultimate Ulcer Cream

Development stage
Unknown
Lead developer
Abler
Modality
Small Molecules
Administration
Oral
01

Overview

Ultimate Ulcer Cream is a veterinary pharmaceutical combination product developed by Abler for the treatment and prevention of Equine Gastric Ulcer Syndrome (EGUS). It contains two active ingredients: omeprazole and ranitidine. Omeprazole is a proton pump inhibitor (PPI) that suppresses gastric acid secretion by irreversibly binding to the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. This action blocks the final transport of hydrogen ions into the gastric lumen, providing long-lasting suppression of acid production. Ranitidine is a histamine H2-receptor antagonist that competitively inhibits the action of histamine on the H2 receptors of parietal cells, leading to a rapid reduction in both the volume and acidity of gastric juice. This dual-mechanism approach is designed to provide both immediate and sustained relief from gastric acidity, facilitating the healing of existing mucosal erosions and protecting the equine stomach lining during periods of stress, high-grain diets, or intense exercise.

Brand names
Ultimate Ulcer CreamAbPrazole Plus
Other names
AbPrazole Plus Paste
02

Targets

ATP4A (Potassium–transporting ATPase alpha chain 1)HRH2 (Histamine H2 Receptor)

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