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UltraSlice
- Development stage
- Preclinical
- Lead developer
- Factor Bioscience
- Modality
- Recombinant Proteins and Enzymes, Cell Therapies, mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Gene Therapies
- Administration
- Ex Vivo
01
Overview
UltraSlice is a gene-editing protein technology platform developed by Factor Bioscience. It utilizes mRNA-based delivery to express gene-editing proteins for efficient and precise transgene insertion into the genome, specifically targeting sites like the TRAC locus in primary human T cells and induced pluripotent stem cells (iPSCs). The platform is designed to support the development of next-generation cell therapies, including allogeneic CAR-T cells, for applications in oncology, autoimmune diseases, and rare diseases. To enhance performance, the technology incorporates modified nucleotides, such as 5-methoxyuridine, which reduce immunogenicity and improve editing efficiency while maintaining high cell viability.
- Brand names
- UltraSlice
02
Targets
gDNA (Genomic DNA at specified editing loci)TCR (T cell antigen receptor complex)
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