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umbilical cord blood platelet lysate
- Development stage
- Phase 2
- Lead developer
- Sciacca Cord Blood Bank
- Administration
- Topical, Ophthalmic
01
Overview
Umbilical cord blood platelet lysate (UCB-PL) is an allogeneic blood-derived biologic therapy produced by the concentration and subsequent lysis of platelets obtained from healthy donor umbilical cord blood. The lysis process, typically achieved through repeated freeze-thaw cycles, releases a potent array of bioactive molecules, including growth factors such as epidermal growth factor (EGF), platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-beta), and vascular endothelial growth factor (VEGF), alongside various anti-inflammatory cytokines. Formulated as an ophthalmic solution, UCB-PL is primarily investigated for the treatment of severe ocular surface disorders that are refractory to conventional therapies, such as persistent corneal ulcers, severe dry eye disease, and ocular manifestations of graft-versus-host disease (GvHD). The therapy functions by stimulating corneal epithelial cell migration and proliferation while suppressing local inflammation, thereby facilitating rapid re-epithelialization and tissue repair.
- Other names
- umbilical cord blood platelet lysateUCB-PLCBPLallogeneic umbilical cord blood platelet lysatehuman umbilical cord blood platelet lysate
02
Targets
EGFR (Epidermal growth factor receptor)FGFR (FGFR family)PDGFRA (Platelet-derived growth factor receptor alpha)VEGFR2 (Vascular endothelial growth factor receptor 2)TGFBR (TGF-beta receptor)VEGFR (VEGFR family)
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