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Umbilical Cord Blood Transplantation-University of British Columbia-hematologic malignancy-bone marrow failure syndrome
- Development stage
- Unknown
- Lead developer
- University of British Columbia
- Modality
- Stem Cell Therapies → Cell Therapies, Small Molecules
- Administration
- Intravenous
01
Overview
Umbilical Cord Blood Transplantation-University of British Columbia-hematologic malignancy-bone marrow failure syndrome refers to a specific clinical trial protocol (NCT00103519) conducted at the University of British Columbia for adult patients with high-risk hematologic malignancies and bone marrow failure syndromes. This therapeutic approach utilizes unrelated umbilical cord blood (UCB) as a source of hematopoietic stem cells to reconstitute the patient's blood and immune systems. The protocol involves a conditioning regimen of fludarabine and total body irradiation (TBI) to facilitate engraftment, followed by the infusion of one or two UCB units. To mitigate the risk of graft-versus-host disease (GVHD), the regimen includes prophylaxis with cyclosporine and mycophenolate mofetil (MMF). This procedure provides a vital alternative for patients who require a stem cell transplant but lack a suitable HLA-matched bone marrow donor.
- Other names
- Umbilical Cord Blood Transplantation as Treatment of Adult Patients With Hematologic DisordersUCBT
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