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Drug intelligence / Profile preview
umbilical cord-derived mesenchymal stem cells (Trustem)
- Development stage
- Unknown
- Lead developer
- TruStem Cell Therapy
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
Umbilical cord-derived mesenchymal stem cells (UC-MSCs) developed by Trustem are an allogeneic cell therapy being evaluated for the treatment of severe COVID-19. These cells possess potent immunomodulatory and anti-inflammatory properties, which are hypothesized to mitigate the systemic hyperinflammation, often referred to as a cytokine storm, and acute respiratory distress syndrome (ARDS) associated with severe SARS-CoV-2 infection. By secreting various paracrine factors and interacting directly with immune cells, UC-MSCs can modulate the activity of T-cells, B-cells, and macrophages, promoting a transition from a pro-inflammatory to an anti-inflammatory environment and supporting lung tissue repair. The therapy is administered via intravenous infusion to provide systemic immunomodulation.
- Other names
- UC-MSCsUmbilical cord mesenchymal stem cellsCELMA
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