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umbilical cord-derived mesenchymal stem cells (Academy of Military Medical Sciences)
- Development stage
- Unknown
- Lead developer
- Academy of Military Medical Sciences
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
Umbilical cord-derived mesenchymal stem cells (UC-MSCs) are an investigational cell therapy being developed by the Affiliated Hospital to Academy of Military Medical Sciences for the treatment of acute graft-versus-host disease (aGVHD). These multipotent stem cells possess significant immunomodulatory properties, including the ability to inhibit T-cell proliferation and modulate the activity of various immune cells such as B-cells, natural killer (NK) cells, and dendritic cells. By secreting anti-inflammatory cytokines and promoting a pro-tolerogenic environment, UC-MSCs aim to mitigate the life-threatening immune response seen in aGVHD following allogeneic hematopoietic stem cell transplantation. The therapy is currently being evaluated in Phase I/II clinical trials to assess its safety and efficacy as an off-the-shelf treatment option.
- Other names
- Human Umbilical Cord Derived MSCUC-MSCs
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