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umbilical cord-derived mesenchymal stem cells (Central Hospital, Nancy, France)
- Development stage
- Unknown
- Lead developer
- CHRU Nancy
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
This investigational cell therapy consists of clinical-grade, allogeneic umbilical cord-derived mesenchymal stem cells (UC-MSCs) developed by the Central Hospital (CHRU de Nancy) in France. The therapy is designed to treat septic shock by modulating the deregulated host immune response. UC-MSCs exert their effects through immunomodulation, reprogramming macrophages and neutrophils toward an anti-inflammatory phenotype, and releasing anti-microbial peptides. The cells are produced under Good Manufacturing Practices (GMP) using culture medium enriched with platelet lysate. Clinical evaluation has progressed to Phase II randomized, placebo-controlled trials focusing on reducing organ failure (measured by SOFA scores) in patients with severe community-acquired septic shock.
- Other names
- UC-MSCsallogeneic mesenchymal stem cellsheterologous mesenchymal stem cellsallogeneic mesenchymal stromal cells
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