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umbilical cord mesenchymal stem cells (Chinese PLA General Hospital, 1e96f3)
- Development stage
- Unknown
- Lead developer
- Chinese PLA General Hospital
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Topical, Intravenous
01
Overview
This investigational cell therapy, developed by the Chinese PLA General Hospital, utilizes human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) for the treatment of severe burns and large-area skin wounds. The therapy aims to accelerate wound healing, promote the regeneration of skin appendages such as sweat glands, and reduce systemic inflammatory complications. hUC-MSCs function primarily through paracrine mechanisms, secreting anti-inflammatory factors like TNF-alpha-induced protein 6 (TSG-6) and pro-angiogenic factors like vascular endothelial growth factor (VEGF). These cells modulate the immune response, reduce oxidative stress, and provide a supportive microenvironment for tissue repair. Clinical trials have evaluated their safety and efficacy when administered topically or in combination with skin grafts.
- Other names
- hUC-MSCshuman umbilical cord mesenchymal stem cells
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