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umbilical cord mesenchymal stem cells (Translational Biosciences, 67889b)
- Development stage
- Unknown
- Lead developer
- Translational Biosciences
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
Umbilical cord mesenchymal stem cells (UC-MSCs) is an investigational allogeneic cell therapy being developed by Translational Biosciences for the treatment of rheumatoid arthritis (RA), specifically for patients who have shown resistance to standard disease-modifying anti-rheumatic drugs (DMARDs). The therapy utilizes mesenchymal stem cells harvested from human umbilical cord tissue, which are expanded and administered intravenously. These cells exhibit potent immunomodulatory and anti-inflammatory properties; they can migrate to sites of inflammation and secrete bioactive molecules that modulate the activity of various immune cells, including T-cells, B-cells, and dendritic cells. By shifting the immune environment from a pro-inflammatory to an anti-inflammatory state, UC-MSCs aim to reduce joint inflammation, prevent structural damage, and induce clinical remission in refractory RA cases.
- Other names
- UC-MSChUC-MSCallogeneic human umbilical cord tissue-derived mesenchymal stem cells
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