Drug intelligence / Profile preview

umbilical cord serum eye drops (Chonnam National University Hospital)

Development stage
Unknown
Lead developer
Chonnam National University Hospital
Administration
Ophthalmic
01

Overview

Umbilical cord serum eye drops is a biologic therapy developed by researchers at Chonnam National University Hospital for the treatment of severe dry eye syndrome. The formulation typically consists of 20% umbilical cord serum derived from umbilical cord blood collected during delivery. This serum contains high concentrations of essential tear components and bioactive factors, including epidermal growth factor (EGF), transforming growth factor-beta (TGF-beta), insulin-like growth factor-1 (IGF-1), nerve growth factor (NGF), vitamin A, and fibronectin. The therapy works by providing a nutrient-rich environment that promotes the proliferation, migration, and differentiation of the ocular surface epithelium, facilitating the repair of keratoepitheliopathy. Clinical research has demonstrated its efficacy in treating severe dry eye associated with Sjögren's syndrome and graft-versus-host disease, often showing superior results compared to autologous serum eye drops.

Other names
20% umbilical cord serum eye dropsUCS eye dropsumbilical cord serumumbilical cord serum-Chonnam National University Hospital
02

Targets

EGFR T790M (Epidermal growth factor receptor T790M mutant)NTRK1 (Tropomyosin-related receptor kinase A)TGFBR (TGF-beta receptor)IGF-1R (Insulin-like growth factor 1 receptor)

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