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Umbilical cord serum eye drops is a biologic therapy developed by researchers at Chonnam National University Hospital for the treatment of severe dry eye syndrome. The formulation typically consists of 20% umbilical cord serum derived from umbilical cord blood collected during delivery. This serum contains high concentrations of essential tear components and bioactive factors, including epidermal growth factor (EGF), transforming growth factor-beta (TGF-beta), insulin-like growth factor-1 (IGF-1), nerve growth factor (NGF), vitamin A, and fibronectin. The therapy works by providing a nutrient-rich environment that promotes the proliferation, migration, and differentiation of the ocular surface epithelium, facilitating the repair of keratoepitheliopathy. Clinical research has demonstrated its efficacy in treating severe dry eye associated with Sjögren's syndrome and graft-versus-host disease, often showing superior results compared to autologous serum eye drops.
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