UNC10112721A

UNC10112721A is a small molecule kinase inhibitor identified in the Published Kinase Inhibitor Set (PKIS) 1 library. It is classified as a cyclin-dependent kinase (CDK) inhibitor, with demonstrated activity against CDK9, CDC-like kinases (CLK1–4), dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), and casein kinase 1 (CSNK1). In preclinical studies, UNC10112721A significantly inhibited the growth of gemcitabine-resistant pancreatic cancer cells, particularly in 3D spheroid models, and increased apoptosis. Among its targets, CDK9 inhibition appeared most relevant to its anticancer effects. UNC10112721A is primarily used as a tool compound in cancer biology and drug discovery research.