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Uncooked cornstarch is a complex carbohydrate used therapeutically as a slow-release source of glucose. It is primarily utilized in the management of hepatic glycogen storage diseases (GSD), particularly types I and III, where it helps maintain normoglycemia and prevent life-threatening hypoglycemia by providing a sustained release of glucose over several hours. It is also used in other conditions characterized by recurrent hypoglycemia, such as insulinoma, especially when standard medical or surgical interventions are contraindicated (e.g., during pregnancy). The therapeutic efficacy is attributed to its high content of slow-digestible starch (SDS) and resistant starch (RS), which are broken down more slowly than simple sugars, thereby providing a steady supply of glucose to the bloodstream.
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