Drug intelligence / Profile preview

unfractionated heparin + low-molecular-weight heparin

Development stage
Preclinical
Modality
Small Molecules
Administration
Intravenous, Subcutaneous
01

Overview

A combination therapy using both unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) simultaneously or sequentially. This approach leverages the complementary mechanisms of these anticoagulants, with UFH primarily inhibiting thrombin (factor IIa) and LMWH having greater activity against factor Xa. The combination has demonstrated synergistic effects in enhancing anti-factor Xa activity and releasing tissue factor pathway inhibitor, providing more effective prevention of venous thrombosis than either agent alone in experimental models.

Brand names
InnohepHeparin
Other names
LMWH + UFH
02

Targets

ATIII (Antithrombin III)Coagulation Factor IXaFXIIa (Coagulation Factor XIIa)Factor XIaF10 (Factor Xa)F2 (Thrombin)

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