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unfractionated heparin + low-molecular-weight heparin
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Intravenous, Subcutaneous
01
Overview
A combination therapy using both unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) simultaneously or sequentially. This approach leverages the complementary mechanisms of these anticoagulants, with UFH primarily inhibiting thrombin (factor IIa) and LMWH having greater activity against factor Xa. The combination has demonstrated synergistic effects in enhancing anti-factor Xa activity and releasing tissue factor pathway inhibitor, providing more effective prevention of venous thrombosis than either agent alone in experimental models.
- Brand names
- LovenoxFragminInnohepHeparin SodiumHeparin
- Other names
- LMWH + UFH
02
Targets
ATIII (Antithrombin III)F10 (Factor Xa)TFPI (Tissue factor pathway inhibitor)F2 (Thrombin)FXIIa (Coagulation Factor XIIa)Factor XIaCoagulation Factor IXa
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