Drug intelligence / Profile preview

Univ. of Michigan STAT3 compound 1

Development stage
Unknown
Lead developer
University of Michigan
01

Overview

Univ. of Michigan STAT3 compound 1: sourced facts only. name: "In direct comparison, our most potent, new STAT3 degrader (compound 1) is >50-times more potent than SD-36 in inducing STAT3 degradation in cells and demonstrates >500-fold degradation selectivity over other STAT members." [DOI:10.1158/1538-7445.am2024-6057]; target: "In direct comparison, our most potent, new STAT3 degrader (compound 1) is >50-times more potent than SD-36 in inducing STAT3 degradation in cells and demonstrates >500-fold degradation selectivity over other STAT members." [DOI:10.1158/1538-7445.am2024-6057]; developer: "1University of Michigan, Ann Arbor, MI." [DOI:10.1158/1538-7445.am2024-6057]; stage: "Compound 1 is very effective in inhibition of tumor growth not only in tumor models responsive to immune checkpoint blockade (ICB) but also in tumor models resistant to ICB." [DOI:10.1158/1538-7445.am2024-6057]

02

Targets

STAT3 (Signal Transducer and Activator of Transcription 3)

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