Drug intelligence / Profile preview

Univ. of Wisconsin-Madison CARM1 compound 3b

Development stage
Unknown
Lead developer
University of Wisconsin–Madison
Modality
PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules
01

Overview

Univ. of Wisconsin-Madison CARM1 compound 3b: sourced facts only. name: "Compound 3b degraded CARM1 in VHL- and proteasome-dependent manner and was highly selective for CARM1 over other protein arginine methyltransferases." [PMID:37703322]; target: "Compound 3b degraded CARM1 in VHL- and proteasome-dependent manner and was highly selective for CARM1 over other protein arginine methyltransferases." [PMID:37703322]; developer: "Lachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States." [PMID:37703322]; modality: "We herein report the development of the proteolysis targeting chimera (PROTAC) for CARM1, which contains a CARM1 ligand TP-064, a linker, and a VHL E3 ligase ligand." [PMID:37703322]

02

Targets

PRMT4 (Protein arginine N-methyltransferase 4)

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