Universität Leipzig ABCG2 compound 8

Universität Leipzig ABCG2 compound 8: sourced facts only. name: "In this study, an N-phenyl-2-carboranylquinazolin-4-amine (8) was designed as inorganic-organic hybrid BCRP inhibitor." [PMID:36988057]; target: "In this study, an N-phenyl-2-carboranylquinazolin-4-amine (8) was designed as inorganic-organic hybrid BCRP inhibitor." [PMID:36988057]; developer: "Institute of Inorganic Chemistry Faculty of Chemistry and Mineralogy, Universität Leipzig, Johannisallee 29, 04103, Leipzig, Germany." [PMID:36988057]; stage: "The carboranylquinazoline 8 further showed the ability to reverse hABCG2-mediated drug resistance in MDCKII-hABCG2 cells by lowering the IC50 value of the BCRP-substrate mitoxantrone, similar to the standard reference and strong inhibitor Ko143, without exhibiting intrinsic toxicity in the lower micromolar ranges." [PMID:36988057]