UnpSiNPs

UnpSiNPs (undecylenic acid-functionalized porous silicon nanoparticles) are an experimental nanomedicine platform designed for the targeted delivery of therapeutic agents, particularly for the treatment of glioblastoma multiforme (GBM). These nanoparticles consist of a porous silicon core that has been surface-modified with undecylenic acid (UA) to enhance stability and provide reactive sites for the attachment of targeting ligands and therapeutic payloads. In preclinical studies, UnpSiNPs are often conjugated with transferrin (Tf) to exploit receptor-mediated transcytosis across the blood-brain barrier (BBB) and are loaded with chemotherapy drugs like doxorubicin or gene therapies like antisense oligonucleotides. The platform aims to overcome the physiological barriers of the central nervous system, allowing for high-payload delivery directly to tumor sites while minimizing systemic toxicity.

Other names

undecylenic acid-functionalized porous silicon nanoparticlesUA-functionalized porous silicon nanoparticles