Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
unrelated donor bone marrow transplant
- Development stage
- Unknown
- Lead developer
- Medical College of Wisconsin
- Modality
- Small Molecules, Recombinant Proteins and Enzymes, Antibody-Based Therapeutics, Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous, Oral, Subcutaneous
01
Overview
This therapeutic protocol refers to an allogeneic hematopoietic stem cell transplantation (HSCT) procedure using bone marrow from a matched unrelated donor (MUD) for the treatment of newly diagnosed severe aplastic anemia (SAA). Investigated by the Medical College of Wisconsin in the BMT CTN 2207 (CureAA) trial, the protocol employs a non-myeloablative conditioning regimen designed to reduce toxicity while ensuring engraftment. The conditioning regimen includes antithymocyte globulin (ATG), fludarabine, cyclophosphamide, and low-dose total body irradiation (TBI). To prevent graft-versus-host disease (GVHD), the protocol utilizes post-transplant cyclophosphamide (PTCy), tacrolimus, and mycophenolate mofetil (MMF). This approach aims to provide a curative option for patients who lack a matched sibling donor, potentially establishing unrelated donor transplant as a viable first-line therapy for SAA.
- Other names
- unrelated donor bone marrow transplant-Medical College of Wisconsin-severe aplastic anemiaCureAAunrelated donor bone marrow transplantation
Beyond the preview
Go deeper on unrelated donor bone marrow transplant.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on unrelated donor bone marrow transplant.